Ketoacidosis
By: Derric Denniston and Liam White McShane
Introduction:
Ketoacidosis is a metabolic state that arises from ketone bodies, these form from fatty acids and amino acids. During Ketoacidosis, the body is unable to properly regulate ketone production. This causes a dramatic increase of keto acids. Ketoacidosis can be fatal but only in extremely rare circumstances. There are generally three common/main types of ketoacidosis: Alcoholic, starvation, and diabetic ketoacidosis.
Diabetic ketoacidosis results in the development of ketone bodies, these can cause insulin deficiencies and dehydration. Specifically, type 1 diabetes obstructs glucose absorption, which will eventually lead to critical glucose and ketone levels in the blood.
Starvation ketoacidosis -
Starvation ketoacidosis will cause a lack of insulin that will result in prolonged starvation. Because of this, there will be an increase in the delivery of free fatty acids to the liver. This will exceed the limit of acetyl-CoA and ketogenesis will result.
Alcoholic Ketoacidosis-
Alcoholic ketoacidosis results in dehydration, which will block the initiation of gluceonogenesis from exhausting the oxalacetate. Eventually, the body will be unable to produce enough glucose which will later result in the formation of ketone bodies, along with fatty acid metabolism.
By: Derric Denniston and Liam White McShane
Introduction:
Ketoacidosis is a metabolic state that arises from ketone bodies, these form from fatty acids and amino acids. During Ketoacidosis, the body is unable to properly regulate ketone production. This causes a dramatic increase of keto acids. Ketoacidosis can be fatal but only in extremely rare circumstances. There are generally three common/main types of ketoacidosis: Alcoholic, starvation, and diabetic ketoacidosis.
Table of Contents
Types:
There are three main types of ketoacidosis:Diabetic ketoacidosis-
Diabetic ketoacidosis results in the development of ketone bodies, these can cause insulin deficiencies and dehydration. Specifically, type 1 diabetes obstructs glucose absorption, which will eventually lead to critical glucose and ketone levels in the blood.
Starvation ketoacidosis -
Starvation ketoacidosis will cause a lack of insulin that will result in prolonged starvation. Because of this, there will be an increase in the delivery of free fatty acids to the liver. This will exceed the limit of acetyl-CoA and ketogenesis will result.
Alcoholic Ketoacidosis-
Alcoholic ketoacidosis results in dehydration, which will block the initiation of gluceonogenesis from exhausting the oxalacetate. Eventually, the body will be unable to produce enough glucose which will later result in the formation of ketone bodies, along with fatty acid metabolism.
Symptoms:
Video:
Links:
https://www.youtube.com/watch?v=tpjVmLIUWCo
https://en.wikipedia.org/wiki/Ketoacidosis
http://www.derangedphysiology.com/main/core-topics-intensive-care/acid-base-disturbances/Chapter%206.1.7/diabetic-alcoholic-and-starvation-ketoacidosis
https://www.gstatic.com/healthricherkp/pdf/diabetic_ketoacidosis.pdf